Mushroom “Vitamin ɗin Dogon Rayuwa” Ya ƙara NAD+ a Berayen Tsohuwa Ta Hanyar H2S
Ergothioneine, sinadarin ƙwaro da ake kira “vitamin ɗin dogon rayuwa,” ya nuna sabuwar hanya da ke haɗa ƙaruwa da ƙara NAD+. A wani bincike da aka wallafa a Cell Metabolism, berayen da suka tsufa kuma aka ba su ET sun samu ƙarin juriya a treadmill, ƙara ƙarfi a tsoka, da hauhawar matakin NAD+. An gano cewa tasirin ya ta’allaka ne da hanyar hydrogen sulfide wadda ke haɗa CSE, persulfidation, da enzyme cGPDH. Idan an cire CSE ko cGPDH, wadannan fa'idodi sun ɓace. Koyaya, binciken an yi shi ne a dabbobi da dakin gwaje‑gwaje, kuma adadin da aka yi amfani da shi a berayen ya kai kusan sau 10 na abin da aka saba samu a ƙwayoyin ƙaruwa.
NR + Pterostilbene na ƙara NAD+ kusan 40–90 % a Gwajin Dan Adam
Shin kowane kwayar NR da pterostilbene na iya ɗaga matakin NAD+ a manya? A gwajin farko akan mutane (NRPT – Basis), mutane 120 masu shekaru 60‑80 sun sha shi na tsawon mako takwas. Hakan ya haifar da ƙaruwa kusan 40 % a ƙimar da ake bada shawara, kuma kusan 90 % a ƙimar da ta ninka. Wannan ƙaruwa ta ci gaba da kasancewa duk tsawon gwajin, ba tare da wani haɗari mai tsanani ba. Ga abin da lambobin suka nuna, yadda za a fassara ƙimar, da kuma abubuwan da binciken ba zai iya amsa ba.
1,000 mg Nicotinamide Riboside a Kullum Yana Kara NAD+ a Kwayoyin Jini Da Kusan 60 % a Manyan Mutane, Binciken Randomized Ya Gano
Binciken da aka wallafa a 2018 a *Nature Communications* ya gwada nicotinamide riboside (NR) a 500 mg sau biyu a rana (jimillar 1,000 mg a rana) tsawon makonni shida a manyan da ke da ƙoshin lafiya. An tabbatar da cewa ba a samu illa ba, sannan amfanin NR ya haɓaka matakin NAD+ a cikin ƙwayoyin garkuwar jini da kusan kashi 60 % idan aka kwatanta da placebo. Masu binciken sun kuma lura da alamu na raguwar hauhawar jini da sassauta jijiyoyin jini, amma ba su da hujja da za su tabbatar da fa’ida, don haka an buƙaci ƙarin gwaje‑gwaje.
Nasara Ta Farko Na NMN a Mutane: 250 mg a Kullum Ya Kara Sensitivity Na Insulin a Tsokar Ƙashi Da Kimanin 25 % a Mata Masu Pre‑diabetes
NMN an dade ana ɗaukar shi a matsayin ‘tauraron ƙasa’ wajen tsawaita rai, amma hujjar ɗan adam ta zo ne ne da sakamakon gwajin Washington University na 2021 da aka wallafa a *Science*. A cikin mata masu post‑menopausal da ke da pre‑diabetes, shan 250 mg na NMN a kowace rana tsawon makonni 10 ya inganta insulin‑sensitivity a tsokar ƙashi da kusan kashi 25 %. Sai dai ba a ga wani tasiri kan matakin sukari a jini ko canjin pre‑diabetes ba.