Mushroom “Vitamin ɗin Dogon Rayuwa” Ya ƙara NAD+ a Berayen Tsohuwa Ta Hanyar H2S
Ergothioneine, sinadarin ƙwaro da ake kira “vitamin ɗin dogon rayuwa,” ya nuna sabuwar hanya da ke haɗa ƙaruwa da ƙara NAD+. A wani bincike da aka wallafa a Cell Metabolism, berayen da suka tsufa kuma aka ba su ET sun samu ƙarin juriya a treadmill, ƙara ƙarfi a tsoka, da hauhawar matakin NAD+. An gano cewa tasirin ya ta’allaka ne da hanyar hydrogen sulfide wadda ke haɗa CSE, persulfidation, da enzyme cGPDH. Idan an cire CSE ko cGPDH, wadannan fa'idodi sun ɓace. Koyaya, binciken an yi shi ne a dabbobi da dakin gwaje‑gwaje, kuma adadin da aka yi amfani da shi a berayen ya kai kusan sau 10 na abin da aka saba samu a ƙwayoyin ƙaruwa.
Fisetin, Senolytic, Ya Tsawaita Rayuwar Beraye—Babu Shaida a Kan Dan Adam
Fisetin, wani flavonoid na tsiro, ya bayyana a matsayin mafi ƙarfi a cikin senolytics daga cikin kwayoyi goma a wani bincike na 2018 da aka wallafa a EBioMedicine. A berayen da suka tsufa, maganin da aka ba su a baya‑bayan nan ya rage alamar senescence, ya rage cututtuka masu alaka da tsufa, kuma ya tsawaita tsawon rayuwar su na matsakaici da iyaka. Amma wannan sakamako na dabbobi ne kawai; har yanzu ba a kammala wani gwajin tsawon rai na mutane ba. Wannan labarin zai fayyace abin da masu binciken suka gano, ma’anar ƙimar da aka yi amfani da ita, da kuma waɗanda ya kamata su bi sahun yayin da ake ci gaba da gwaje‑gwajen ɗan adam.
Epithalon Na Kunnawa Telomerase a Kwayoyin—Ba a Mutane
Epithalon, peptide mai ƙwayoyin amino huɗu da aka ce yana kunna telomerase, an nuna yana tsawaita telomeres a ƙwayoyin ɗan adam a dakin gwaje‑gwaje. Sai dai binciken ya yi a kan fibroblasts na jariri a cikin tukunya, ba a kan mutane ba, kuma babu hujja da ke tabbatar da cewa hakan zai tsawaita rayuwar ɗan adam.
Rapamycin Sau Daya a Kowane Mako na Shekara: Lafiya, Amma Shin Kitse na Ciki Ya Sauya?
Kowa na son sanin ko shan rapamycin sau ɗaya a mako zai rage kitse a cikin ciki kuma ya ƙara tsawon lokacin lafiya. Gwajin PEARL ya ba da amsoshi masu ban mamaki: bayan makonni 48 da aka yi wa manya masu lafiya, ba a ga wani canji a adadin kitse na ciki ba, kuma amincin maganin ya yi kama da na placebo. Wasu alamu na biyu – kamar ƙaruwa a ƙwayar ƙiba da rage radadi a mata masu sha 10 mg, da kuma jin daɗi mafi kyau a ƙungiyar 5 mg – suna nuna yiwuwar fa'ida, amma sakamakon na ƙananan rukuni ne kuma ba su tabbatar da tsawaita rayuwa ba. Ga abin da aka samu da abin da ba a samu ba.
Vitamin D3 Ya Dakile Raguwar Telomere da 140 Base Pairs a Gwajin RCT na Shekaru 4
Wani babban gwaji mai kulawa da placebo ya gano cewa shan vitamin D3 tsawon shekaru hudu ya rage raguwar telomere da kusan 140 base pairs. Bayanai sun fito daga binciken VITAL da aka gudanar a kan manyan 'yan Amurka masu shan 2,000 IU a kowace rana. Tasirin ya kasance kanana (p = 0.039), kuma tsawon telomere alama ce kawai, ba hujjar tsawon rai ba. Omega‑3 a wannan gwaji ba ta nuna wani tasiri kan telomere ba. Ga abin da lambobin ke nuna, iyakokinsu, da yadda za a fassara sakamakon.
Omega-3 Ya Rage Tsufan Halitta Da Kimanin Watanni 3 Cikin Gwajin Shekara 3
Wani gwajin bazuwar da aka yi wa mutane 777 masu shekaru 70 da sama ya gano cewa gram 1 na omega‑3 a kowace rana yana rage agogon epigenetic da kusan watanni 3 na tsufan halitta a cikin shekaru uku. Hada omega‑3 da bitamin D (2,000 IU a rana) da wani sauƙi na motsa jiki a gida ya nuna ƙarin fa'ida a kan agogon PhenoAge. Abin da ya kamata a sani shi ne tasirin yana da ƙanƙanta, binciken an yi shi kwanan nan, kuma agogon epigenetic alamu ne kawai, ba hujja ta tsawon rayuwa ba. Wannan nazari ya bayyana adadi, ƙuntatawa, da ƙimar da aka yi amfani da su, tare da shawarar duba likita kafin a fara.
Calcium Alpha‑Ketoglutarate Ya Kara Tsawon Rayuwar Berayen Mata Har Zuwa 16.6% – Menene Ake Nufi Da Abin Da Ba A Nufi Ba?
Binciken da aka wallafa a mujallar *Cell Metabolism* (2020) ya nuna cewa ciyar da berayen da suka kai tsakiyar shekarunsu da abincin da ke ɗauke da 2 % calcium alpha‑ketoglutarate (CaAKG) ya ƙara wa mata tsawon rai har zuwa 16.6 % kuma ya rage kamuwa da rauni. Amma sakamakon ya shafi beraye ne kawai, ba ya nufin zai yi tasiri iri ɗaya a jikin ɗan adam ba.
1,000 mg Nicotinamide Riboside a Kullum Yana Kara NAD+ a Kwayoyin Jini Da Kusan 60 % a Manyan Mutane, Binciken Randomized Ya Gano
Binciken da aka wallafa a 2018 a *Nature Communications* ya gwada nicotinamide riboside (NR) a 500 mg sau biyu a rana (jimillar 1,000 mg a rana) tsawon makonni shida a manyan da ke da ƙoshin lafiya. An tabbatar da cewa ba a samu illa ba, sannan amfanin NR ya haɓaka matakin NAD+ a cikin ƙwayoyin garkuwar jini da kusan kashi 60 % idan aka kwatanta da placebo. Masu binciken sun kuma lura da alamu na raguwar hauhawar jini da sassauta jijiyoyin jini, amma ba su da hujja da za su tabbatar da fa’ida, don haka an buƙaci ƙarin gwaje‑gwaje.
Taurine, Sinadarin Amino Mai Araha da Ya Tsawaita Rayuwar Kunkuru da Kusan 12% Kuma Yana Raguwa da Yawan Taurine a Jinin Mutane
Binciken *Science* na 2023 ya gano cewa matakin taurine a jini – sinadarin amino mai araha da ake samu a ko'ina – yana raguwa da tsufa a cikin kunkuru, birai da mutane. Sa ran taurine ga kunkuru a tsakiyar rayuwa ya ƙara musu tsawon rai da kusan kashi 10‑12% tare da inganta lafiyarsu gaba ɗaya. An ga taurine na rage alamun tsufar ƙwayoyin, lalacewar DNA, matsalolin mitochondria da kumburin da ake kira “inflammaging”. Duk da haka, hujjojin daga mutane na ƙalla‑kalla ne, kuma ƙididdigar da aka samu a kunkuru tana nufin gram‑grama da yawa a kullum. Saboda haka masana sun ƙara jaddada buƙatar ƙarin gwaje‑gwaje kafin a ɗauki taurine a matsayin maganin tsufa.