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Longevity

Multivitamin Na Kullum Ya Rage Gudun Tsufar Epigenetic a Binciken COSMOS

Dr. Synapse · · 5 min read
#longevity #epigenetic clocks #biological aging #multivitamin #cosmos trial #cocoa flavanols #dna methylation

Multivitamin Na Kullum Ya Rage Gudun Tsufar Epigenetic a Binciken COSMOS

Multivitamin mai araha da ake samu a ko'ina na iya sauya yadda agogo na epigenetic ke gudana. Sabon bincike da aka gudanar a cikin shirin COSMOS, kuma aka buga a Nature Medicine a shekarar 2026, ya nuna cewa shan multivitamin‑multimineral (MVM) a kullum yana rage saurin agogo biyu na epigenetic a manya. A gefe guda, shan cocoa ba shi da tasiri a kan waɗannan agogo. Tasirin yana da ƙanana, kuma har yanzu ba a san ko zai haifar da rayuwa mafi lafiya ko tsayi ba.

Abin Da Masana Suka Gwada

COSMOS (COcoa Supplement and Multivitamin Outcomes Study) babbar gwaji ce da aka yi a manya don tantance hanyoyi biyu: multivitamin a kullum da shan cocoa a kullum. Binciken baya ya nuna cewa waɗannan ƙari na iya rage wasu cututtuka masu alaka da tsufa, amma ba a san ko suna tasiri kai tsaye a kan alamar tsufa ta DNA methylation ba.

An horar da mahalarta 958 (mata 482 da maza 476) kuma an auna matakan DNA methylation na su tsawon shekaru biyu. An yi amfani da hanyoyi uku:

  • Multivitamin‑multimineral: Centrum Silver, samfurin OTC da aka ƙera musamman ga manya masu shekaru 50 da sama, ana shan sa a kowace rana.
  • Cocoa extract: 500 mg flavanols na cocoa a rana, ciki har da 80 mg (‑)-epicatechin.
  • Placebo: maganin da ba shi da wani abu da zai yi tasiri.

An auna tsufar jiki da agogo guda biyar na DNA methylation: PCGrimAge, PCPhenoAge, PCHannum, PCHorvath da DunedinPACE. "PC" na nufin agogo da aka gina daga manyan sassa (principal components) don rage hayaniya da ƙara sahihanci.

Sakamakon Da Ya Fi Fitowa

Idan aka kwatanta da placebo, multivitamin ya rage saurin ƙara shekaru a kan agogo biyu na epigenetic:

  • PCGrimAge: bambanci na ‑0.113 shekara a kowace shekara (95 % CI: ‑0.205 zuwa ‑0.020; P = 0.017).
  • PCPhenoAge: bambanci na ‑0.214 shekara a kowace shekara (95 % CI: ‑0.410 zuwa ‑0.019; P = 0.032).

A sauƙaƙe, a kowace shekara mutanen da ke shan multivitamin sun ga PCGrimAge ya ƙaru 0.11 shekara ƙasa da masu placebo, kuma PCPhenoAge ya ƙaru 0.21 shekara ƙasa. Idan aka miƙa wannan lamari tsawon shekaru biyu, zai haifar da bambanci na ƙwanan wata kaɗan a kan agogo. Amma bambance‑bambancen suna da faɗin igiya mai fadi, kuma canjin agogo ba lallai ne ya nufin canjin lafiyar jiki ba.

Agogo uku na ƙarshe — PCHannum, PCHorvath da DunedinPACE — ba su nuna wani tasiri mai ma'ana na multivitamin ba.

Tasiri Mai Girma A Cikin Mutanen Da Suka Tsufa Da Sauri

Abin da ya fi jan hankali shi ne yadda mutanen da ke da saurin tsufa suka fi amfana. Lokacin da aka raba mahalarta bisa matakin tsufar jiki a farkon gwaji, tasirin multivitamin a kan PCGrimAge ya fi ƙarfi a tsakanin waɗanda ke da tsufar da ta hauhawa (‑0.236 shekara a kowace shekara, 95 % CI: ‑0.380 zuwa ‑0.091). A tsakanin masu matsakaicin ko ƙananan tsufa, tasirin ya kusan zama babu (‑0.013, 95 % CI: ‑0.130 zuwa 0.104). Wannan bambanci yana da muhimmanci (P = 0.018).

Wannan yana nuni da cewa mutanen da ke da alamun tsufa da sauri na iya samun fa'ida mai girma daga kari na multivitamin, watakila saboda ƙara samun sinadaran da jikin su ke bukata. Sai dai, wannan ƙididdigar ƙungiya ce kuma dole ne a sake gwada ta a cikin wasu bincike.

Flavanols Na Cocoa: Rashin Tasiri

Cocoa extract an ɗauke shi a matsayin kari mai fa'ida ga zuciya da kwakwalwa, kuma flavanols na cocoa sukan kasance a kasuwa da tallan "anti‑aging". A wannan gwaji, duk da shan 500 mg flavanols a rana, ba a ga wani tasiri a kan kowanne daga cikin agogo biyar ba. Wannan ba yana nufin cocoa ba shi da wani amfani ba — yana iya taimakawa a wasu fannoni kamar lafiyar jijiyoyin jini — amma a alamar tsufar epigenetic ba a ga wani canji ba a wannan lokacin da tsawon gwajin.

Yaya Ya Kamata Mu Fahimta?

Masu binciken sun rubuta cewa tasirin "statistically significant but small" kuma "encouraging", suna jaddada bukatar ƙarin bincike don tantance muhimmancin su a kliniki. Abubuwan da ya kamata a la’akari da su:

  • Agogo na epigenetic su ne alamomin maye. Suna da alaƙa da cututtuka da haɗarin mutuwa, amma ba a tabbatar da cewa canza su zai canza sakamakon mutum ba.
  • Girman tasiri ƙanana kuma igiyoyin amincewa suna faɗi. Daga cikin agogo biyar, biyu ne kawai suka nuna bambanci, kuma ƙimar P (0.017 da 0.032) ba su da ƙarfi sosai, musamman idan an yi gwaje‑gwaje da yawa.
  • Shekaru biyu ba su daɗe ba. Ba a san ko bambancin zai ci gaba, ya tsaya ko ya ɓace a cikin lokaci mai tsawo ba.
  • Ba a san wane sinadari ne ke haifar da tasirin ba. Multivitamin ya ƙunshi sinadarai da dama; wannan gwaji ba zai iya tantance wanda ke da hakkin tasirin ba.

Abubuwan Da Za a Iya Amfani Da Su A Rayuwa

  • Abin da za a sha: Centrum Silver guda ɗaya a rana, multivitamin mai araha da ake samu a ƙasuwanni, ba wani mugun sirrin ƙara tsufa ba.
  • Waɗanda za su iya amfana sosai: Manyan mutane da ke da saurin tsufa na iya samun ƙarin fa'ida, ko da yake mafi yawan mutane ba za su iya auna matakin epigenetic ɗinsu ba, kuma agogo na kasuwa suna da bambance‑bambancen inganci.
  • Flavanols na cocoa: Kada ku yi tsammanin za ku samu fa'ida a agogo na methylation daga cocoa. Ku ci cocoa idan kuna son dandano ko wasu fa'ida, amma wannan gwaji ba ya tallafa wa shi a matsayin kayan anti‑aging na epigenetic.
  • Kasance da gaskiya: Multivitamin ba zai maye gurbin cin abinci mai gina jiki, motsa jiki, barci mai kyau, ko kulawar likita ba. Hujjar amfanin da aka samu daga wannan tasirin har yanzu tana buƙatar ƙarin ƙididdiga.

Kammalawa

Binciken epigenetic na COSMOS ɗaya ne daga cikin manyan gwaje‑gwajen da aka yi don gano ko wani kari na yau da kullum yana shafar alamar tsufa ta DNA methylation. Ya ba da alamar ƙanana amma tabbatacciyar tasiri ga multivitamin, kuma ya ƙara haske ga muzuwa puzzle ɗin tsufa — ba hukunci ba. Sai a jira ƙarin gwaje‑gwaje masu tsawo don tabbatar da cewa raguwar agogo na nufin ingantaccen lafiyar jiki.

Original study

Read the original research on pubmed.ncbi.nlm.nih.gov →

This article summarizes published research for general information. It is not medical advice.

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DS

Written by

Dr. Synapse

Dr. Synapse writes for Biocracked: biohacking science, longevity & human performance.

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