Shekara guda da aka sha DHA ta rage raguwa a hippocampus, wuri mai matukar muhimmanci wajen tunawa, a manya da ke da Matsakaicin Nakasa na Tunani (MCI). A cikin gwaji mai ƙau da 240 daga China (219 suka kammala), ƙungiyar da ta karɓi DHA ta samu sakamako mafi kyau a gwaje‑gwajen IQ, Bayani da Digit Span idan aka kwatanta da placebo. Kadarar da aka ba ita ita ce ƙara 2 g na DHA a rana, wanda a zahiri ya kai kusan 0.9 g na DHA. Sakamakon na iya bayyana dalilin da ya sa gwaje‑gwajen omega‑3 a cikin mutane masu lafiya ba su ba da sakamako ba, domin fa'ida na iya iyakantuwa ga waɗanda ke fama da raguwar tunani. Wannan rubutun ya tattauna lambobin sakamako, hanyoyin da ake tunanin DHA ke aiki, shawarar adadi da asalin DHA, da iyakokin gwajin.
Anserine, wani dipeptide da ake samu a nonon kaza, ya ba da sakamako mai ban mamaki ga waɗanda ke da *mild cognitive impairment* (MCI). A gwajin bazuwar tsawon makonni 12, shan miligram 500 a kowace rana ya ƙara kusan maki 1.9 a gwajin MMSE, yayin da ƙungiyar placebo ba ta nuna wani canji (p = 0.036). An yi zaton yadda yake aiki ne ta hanyar tsarewa ko ɗaukar sinadarin hypochlorous acid, wanda ke ƙara kumburin kwakwalwa. Ko da yake bayanan na da iyaka – mutane 30 kawai a gwaji guda ɗaya – wannan bincike yana ba da haske kan yiwuwar anserine a matsayin ƙarin abinci don inganta tunawa.
Wani kananan gwaji da aka gudanar a Norway ya gano cewa shan gram 12 na hydrolysate furotin na salmon a kowace rana na tsawon makonni takwas ya ƙara ferritin da kusan kashi 13 % da ƙwayoyin jini ja da kashi 7 % idan an kwatanta da whey protein. Sakamakon ya kuma nuna ragin kumburi, ingantaccen sukari a jini, da canje‑canjen yanayin jiki. Amma gwajin ya ƙunshi mutane 14 kacal, kuma kamfanin da ya samar da samfurin ne ya tallafa masa, don haka sakamakon ba zai zama hujja ba, alama ce kawai.
Wani gwaji na bazuwar da aka gudanar a shekarar 2024 ya gwada maganin magnesium da ke ƙara magnesium a kwakwalwa, magnesium L‑threonate (Magtein), a kan manyan mutane 80 da ke da matsalolin barci. Bayan kwanaki 21 da shan gram 1 a rana, rukunin da ya sha MgT ya samu maki mafi girma a bacci mai zurfi da REM a kan abin daidaita barci na Oura fiye da rukunin placebo, tare da ingantaccen yanayi, ƙarfi da faɗakarwa. Koyaya, ƙungiyar placebo ma ta fara tabarbarewa, auna matakan barci ya dogara ne kan na’urar da aka saya don amfani na yau da kullum, ba a asibiti ba, kuma ba a kwatanta threonate da glycinate ko citrate ba. Wannan shi ne ainihin sakamakon, yawan magnesium da gram 1 ke ƙunshe da shi, da ƙalubalen da ke tattare da shi.
Ergothioneine, sinadarin ƙwaro da ake kira “vitamin ɗin dogon rayuwa,” ya nuna sabuwar hanya da ke haɗa ƙaruwa da ƙara NAD+. A wani bincike da aka wallafa a Cell Metabolism, berayen da suka tsufa kuma aka ba su ET sun samu ƙarin juriya a treadmill, ƙara ƙarfi a tsoka, da hauhawar matakin NAD+. An gano cewa tasirin ya ta’allaka ne da hanyar hydrogen sulfide wadda ke haɗa CSE, persulfidation, da enzyme cGPDH. Idan an cire CSE ko cGPDH, wadannan fa'idodi sun ɓace. Koyaya, binciken an yi shi ne a dabbobi da dakin gwaje‑gwaje, kuma adadin da aka yi amfani da shi a berayen ya kai kusan sau 10 na abin da aka saba samu a ƙwayoyin ƙaruwa.
GHK‑Cu, peptide mai ɗauke da ƙarfe da ake samu a cikin yawancin serum, na iya yin fiye da sanya fata ta riƙe ruwa. Binciken da aka wallafa a 2018 ya nuna cewa bayanan fitar da kwayoyin halitta na iya bayyana yadda wannan ƙwayar ƙanana ke taimakawa wajen ƙirƙirar ƙolajen, gyaran sel, rage kumburi, har da gyaran DNA. Wannan shi ne ainihin abin da takardar ke magana akai game da tsufar fata, sabunta ta, da iyakokin hujjojin da ke akwai. Kafin ka yarda da tallan ƙwarai, karanta ƙuntatawar da suka shafi amfani da su a kan fata da abin da binciken zai iya ko ba zai iya tabbatarwa ba.
Fisetin, wani flavonoid na tsiro, ya bayyana a matsayin mafi ƙarfi a cikin senolytics daga cikin kwayoyi goma a wani bincike na 2018 da aka wallafa a EBioMedicine. A berayen da suka tsufa, maganin da aka ba su a baya‑bayan nan ya rage alamar senescence, ya rage cututtuka masu alaka da tsufa, kuma ya tsawaita tsawon rayuwar su na matsakaici da iyaka. Amma wannan sakamako na dabbobi ne kawai; har yanzu ba a kammala wani gwajin tsawon rai na mutane ba. Wannan labarin zai fayyace abin da masu binciken suka gano, ma’anar ƙimar da aka yi amfani da ita, da kuma waɗanda ya kamata su bi sahun yayin da ake ci gaba da gwaje‑gwajen ɗan adam.
Epithalon, peptide mai ƙwayoyin amino huɗu da aka ce yana kunna telomerase, an nuna yana tsawaita telomeres a ƙwayoyin ɗan adam a dakin gwaje‑gwaje. Sai dai binciken ya yi a kan fibroblasts na jariri a cikin tukunya, ba a kan mutane ba, kuma babu hujja da ke tabbatar da cewa hakan zai tsawaita rayuwar ɗan adam.
Shin kowane kwayar NR da pterostilbene na iya ɗaga matakin NAD+ a manya? A gwajin farko akan mutane (NRPT – Basis), mutane 120 masu shekaru 60‑80 sun sha shi na tsawon mako takwas. Hakan ya haifar da ƙaruwa kusan 40 % a ƙimar da ake bada shawara, kuma kusan 90 % a ƙimar da ta ninka. Wannan ƙaruwa ta ci gaba da kasancewa duk tsawon gwajin, ba tare da wani haɗari mai tsanani ba. Ga abin da lambobin suka nuna, yadda za a fassara ƙimar, da kuma abubuwan da binciken ba zai iya amsa ba.
Kowa na son sanin ko shan rapamycin sau ɗaya a mako zai rage kitse a cikin ciki kuma ya ƙara tsawon lokacin lafiya. Gwajin PEARL ya ba da amsoshi masu ban mamaki: bayan makonni 48 da aka yi wa manya masu lafiya, ba a ga wani canji a adadin kitse na ciki ba, kuma amincin maganin ya yi kama da na placebo. Wasu alamu na biyu – kamar ƙaruwa a ƙwayar ƙiba da rage radadi a mata masu sha 10 mg, da kuma jin daɗi mafi kyau a ƙungiyar 5 mg – suna nuna yiwuwar fa'ida, amma sakamakon na ƙananan rukuni ne kuma ba su tabbatar da tsawaita rayuwa ba. Ga abin da aka samu da abin da ba a samu ba.
Wani ƙaramar gwaji na 2008 ya sanya berberine a tare da metformin a cikin masu sabuwar ganewar cutar suga na nau’in 2, kuma tasirin rage suga ya yi kama. A ƙungiyar berberine, HbA1c ya sauka daga 9.5 % zuwa 7.5 % a cikin watanni uku. Wani gwaji na biyu da ya yi a kan mutane 48 da ke riga suna kan magani ya nuna HbA1c ya sauka daga 8.1 % zuwa 7.3 % haka kuma HOMA‑IR ya ragu da 44.7 %. Amma waɗannan ƙananan bincike ne a tsakanin masu ciwon suga, kuma kusan kashi ɗaya‑uku na mahalarta sun fuskanci matsalolin hanji. Ga abin da bayanai suke nuna, abin da ba su nuna ba, da abubuwan da ya kamata ku sani kafin ku yanke shawarar amfani da berberine.

Ergothioneine, sinadarin ƙwaro da ake kira “vitamin ɗin dogon rayuwa,” ya nuna sabuwar hanya da ke haɗa ƙaruwa da ƙara NAD+. A wani bincike da aka wallafa a Cell Metabolism, berayen da suka tsufa kuma aka ba su ET sun samu ƙarin juriya a treadmill, ƙara ƙarfi a tsoka, da hauhawar matakin NAD+. An gano cewa tasirin ya ta’allaka ne da hanyar hydrogen sulfide wadda ke haɗa CSE, persulfidation, da enzyme cGPDH. Idan an cire CSE ko cGPDH, wadannan fa'idodi sun ɓace. Koyaya, binciken an yi shi ne a dabbobi da dakin gwaje‑gwaje, kuma adadin da aka yi amfani da shi a berayen ya kai kusan sau 10 na abin da aka saba samu a ƙwayoyin ƙaruwa.
Fisetin, wani flavonoid na tsiro, ya bayyana a matsayin mafi ƙarfi a cikin senolytics daga cikin kwayoyi goma a wani bincike na 2018 da aka wallafa a EBioMedicine. A berayen da suka tsufa, maganin da aka ba su a baya‑bayan nan ya rage alamar senescence, ya rage cututtuka masu alaka da tsufa, kuma ya tsawaita tsawon rayuwar su na matsakaici da iyaka. Amma wannan sakamako na dabbobi ne kawai; har yanzu ba a kammala wani gwajin tsawon rai na mutane ba. Wannan labarin zai fayyace abin da masu binciken suka gano, ma’anar ƙimar da aka yi amfani da ita, da kuma waɗanda ya kamata su bi sahun yayin da ake ci gaba da gwaje‑gwajen ɗan adam.
Kowa na son sanin ko shan rapamycin sau ɗaya a mako zai rage kitse a cikin ciki kuma ya ƙara tsawon lokacin lafiya. Gwajin PEARL ya ba da amsoshi masu ban mamaki: bayan makonni 48 da aka yi wa manya masu lafiya, ba a ga wani canji a adadin kitse na ciki ba, kuma amincin maganin ya yi kama da na placebo. Wasu alamu na biyu – kamar ƙaruwa a ƙwayar ƙiba da rage radadi a mata masu sha 10 mg, da kuma jin daɗi mafi kyau a ƙungiyar 5 mg – suna nuna yiwuwar fa'ida, amma sakamakon na ƙananan rukuni ne kuma ba su tabbatar da tsawaita rayuwa ba. Ga abin da aka samu da abin da ba a samu ba.
Wani babban gwaji mai kulawa da placebo ya gano cewa shan vitamin D3 tsawon shekaru hudu ya rage raguwar telomere da kusan 140 base pairs. Bayanai sun fito daga binciken VITAL da aka gudanar a kan manyan 'yan Amurka masu shan 2,000 IU a kowace rana. Tasirin ya kasance kanana (p = 0.039), kuma tsawon telomere alama ce kawai, ba hujjar tsawon rai ba. Omega‑3 a wannan gwaji ba ta nuna wani tasiri kan telomere ba. Ga abin da lambobin ke nuna, iyakokinsu, da yadda za a fassara sakamakon.
Wani gwajin bazuwar da aka yi wa mutane 777 masu shekaru 70 da sama ya gano cewa gram 1 na omega‑3 a kowace rana yana rage agogon epigenetic da kusan watanni 3 na tsufan halitta a cikin shekaru uku. Hada omega‑3 da bitamin D (2,000 IU a rana) da wani sauƙi na motsa jiki a gida ya nuna ƙarin fa'ida a kan agogon PhenoAge. Abin da ya kamata a sani shi ne tasirin yana da ƙanƙanta, binciken an yi shi kwanan nan, kuma agogon epigenetic alamu ne kawai, ba hujja ta tsawon rayuwa ba. Wannan nazari ya bayyana adadi, ƙuntatawa, da ƙimar da aka yi amfani da su, tare da shawarar duba likita kafin a fara.

Wani kananan gwaji da aka gudanar a Norway ya gano cewa shan gram 12 na hydrolysate furotin na salmon a kowace rana na tsawon makonni takwas ya ƙara ferritin da kusan kashi 13 % da ƙwayoyin jini ja da kashi 7 % idan an kwatanta da whey protein. Sakamakon ya kuma nuna ragin kumburi, ingantaccen sukari a jini, da canje‑canjen yanayin jiki. Amma gwajin ya ƙunshi mutane 14 kacal, kuma kamfanin da ya samar da samfurin ne ya tallafa masa, don haka sakamakon ba zai zama hujja ba, alama ce kawai.
GHK‑Cu, peptide mai ɗauke da ƙarfe da ake samu a cikin yawancin serum, na iya yin fiye da sanya fata ta riƙe ruwa. Binciken da aka wallafa a 2018 ya nuna cewa bayanan fitar da kwayoyin halitta na iya bayyana yadda wannan ƙwayar ƙanana ke taimakawa wajen ƙirƙirar ƙolajen, gyaran sel, rage kumburi, har da gyaran DNA. Wannan shi ne ainihin abin da takardar ke magana akai game da tsufar fata, sabunta ta, da iyakokin hujjojin da ke akwai. Kafin ka yarda da tallan ƙwarai, karanta ƙuntatawar da suka shafi amfani da su a kan fata da abin da binciken zai iya ko ba zai iya tabbatarwa ba.
Epithalon, peptide mai ƙwayoyin amino huɗu da aka ce yana kunna telomerase, an nuna yana tsawaita telomeres a ƙwayoyin ɗan adam a dakin gwaje‑gwaje. Sai dai binciken ya yi a kan fibroblasts na jariri a cikin tukunya, ba a kan mutane ba, kuma babu hujja da ke tabbatar da cewa hakan zai tsawaita rayuwar ɗan adam.
Collagen ɗaya daga manyan abubuwan da ake nema a fannin kwalliya da tsawon rai, amma mafi yawan samfuran suna da takardun placebo ne kawai. A wani gwaji da mata 114 masu shekaru 45‑65 suka halarta, gram 2.5 na takamaiman peptide mai aiki Verisol ya rage ƙyallin tabon idanu da kashi 20 % idan aka kwatanta da placebo bayan makonni 8. Biopsies sun nuna ƙaruwa a procollagen I da kashi 65 % da elastin da kashi 18 %, yayin da ƙaruwa a fibrillin (6 %) ba ta da muhimmanci.
Peptaid ɗin MOTS‑c mai ƙwayoyin 16 wanda ake samu a cikin mtDNA ya ƙunshi siginar da ke kunna AMPK a tsokar ƙashi, tare da rage rashin juriya ga insulin da kiba da abinci mai kitse, a cewar wani binciken *Cell Metabolism* na 2015. Duk da cike da sha‑sha a sashen peptides da bio‑hacking, ƙididdigar ta ta’allaka ne kan beraye da kwayoyin ƙwaya, ba a gwada a kan mutane ba, kuma ba a amince da MOTS‑c a matsayin magani ba. Wannan labarin zai fayyace menene MOTS‑c, yadda yake aiki, abin da gwaje‑gwajen beraye suka nuna, da kuma abubuwan da ba za a ɗauka a matsayin hujja ba.
Wani babban gwaji mai kulawa da placebo ya gano cewa shan vitamin D3 tsawon shekaru hudu ya rage raguwar telomere da kusan 140 base pairs. Bayanai sun fito daga binciken VITAL da aka gudanar a kan manyan 'yan Amurka masu shan 2,000 IU a kowace rana. Tasirin ya kasance kanana (p = 0.039), kuma tsawon telomere alama ce kawai, ba hujjar tsawon rai ba. Omega‑3 a wannan gwaji ba ta nuna wani tasiri kan telomere ba. Ga abin da lambobin ke nuna, iyakokinsu, da yadda za a fassara sakamakon.
Collagen ɗaya daga manyan abubuwan da ake nema a fannin kwalliya da tsawon rai, amma mafi yawan samfuran suna da takardun placebo ne kawai. A wani gwaji da mata 114 masu shekaru 45‑65 suka halarta, gram 2.5 na takamaiman peptide mai aiki Verisol ya rage ƙyallin tabon idanu da kashi 20 % idan aka kwatanta da placebo bayan makonni 8. Biopsies sun nuna ƙaruwa a procollagen I da kashi 65 % da elastin da kashi 18 %, yayin da ƙaruwa a fibrillin (6 %) ba ta da muhimmanci.
Binciken farko na farfadowa da **Akkermansia muciniphila** a kan mutane masu kiba da rashin amsawar insulin ya nuna ƙaruwa 28.6 % a ƙwarewar insulin da raguwar insulin a jini da 34.1 % idan aka kwatanta da placebo. Ragin nauyi da kitse ba su kai matakin ƙididdiga ba, kuma wasu marubuta suna da hannun jari a kamfanin da ke sayar da wannan kwaya. Ga abin da binciken ya gano, abubuwan da ba a faɗa ba, da abin da ya kamata ku duba kafin sayen kari.
Wani gwajin bazuwar da aka yi wa mutane 777 masu shekaru 70 da sama ya gano cewa gram 1 na omega‑3 a kowace rana yana rage agogon epigenetic da kusan watanni 3 na tsufan halitta a cikin shekaru uku. Hada omega‑3 da bitamin D (2,000 IU a rana) da wani sauƙi na motsa jiki a gida ya nuna ƙarin fa'ida a kan agogon PhenoAge. Abin da ya kamata a sani shi ne tasirin yana da ƙanƙanta, binciken an yi shi kwanan nan, kuma agogon epigenetic alamu ne kawai, ba hujja ta tsawon rayuwa ba. Wannan nazari ya bayyana adadi, ƙuntatawa, da ƙimar da aka yi amfani da su, tare da shawarar duba likita kafin a fara.
Peptaid ɗin MOTS‑c mai ƙwayoyin 16 wanda ake samu a cikin mtDNA ya ƙunshi siginar da ke kunna AMPK a tsokar ƙashi, tare da rage rashin juriya ga insulin da kiba da abinci mai kitse, a cewar wani binciken *Cell Metabolism* na 2015. Duk da cike da sha‑sha a sashen peptides da bio‑hacking, ƙididdigar ta ta’allaka ne kan beraye da kwayoyin ƙwaya, ba a gwada a kan mutane ba, kuma ba a amince da MOTS‑c a matsayin magani ba. Wannan labarin zai fayyace menene MOTS‑c, yadda yake aiki, abin da gwaje‑gwajen beraye suka nuna, da kuma abubuwan da ba za a ɗauka a matsayin hujja ba.
Binciken da aka wallafa a mujallar *Cell Metabolism* (2020) ya nuna cewa ciyar da berayen da suka kai tsakiyar shekarunsu da abincin da ke ɗauke da 2 % calcium alpha‑ketoglutarate (CaAKG) ya ƙara wa mata tsawon rai har zuwa 16.6 % kuma ya rage kamuwa da rauni. Amma sakamakon ya shafi beraye ne kawai, ba ya nufin zai yi tasiri iri ɗaya a jikin ɗan adam ba.