Magnesium L‑Threonate Ya Kara Mafi Kyawun Bacci Mai Zurfi da REM a Kan Oura Bayan Kwanaki 21
Wani gwaji na bazuwar da aka gudanar a shekarar 2024 ya gwada maganin magnesium da ke ƙara magnesium a kwakwalwa, magnesium L‑threonate (Magtein), a kan manyan mutane 80 da ke da matsalolin barci. Bayan kwanaki 21 da shan gram 1 a rana, rukunin da ya sha MgT ya samu maki mafi girma a bacci mai zurfi da REM a kan abin daidaita barci na Oura fiye da rukunin placebo, tare da ingantaccen yanayi, ƙarfi da faɗakarwa. Koyaya, ƙungiyar placebo ma ta fara tabarbarewa, auna matakan barci ya dogara ne kan na’urar da aka saya don amfani na yau da kullum, ba a asibiti ba, kuma ba a kwatanta threonate da glycinate ko citrate ba. Wannan shi ne ainihin sakamakon, yawan magnesium da gram 1 ke ƙunshe da shi, da ƙalubalen da ke tattare da shi.
Berberine da Metformin: Gwajin Farko da ya rage HbA1c daga 9.5% zuwa 7.5%
Wani ƙaramar gwaji na 2008 ya sanya berberine a tare da metformin a cikin masu sabuwar ganewar cutar suga na nau’in 2, kuma tasirin rage suga ya yi kama. A ƙungiyar berberine, HbA1c ya sauka daga 9.5 % zuwa 7.5 % a cikin watanni uku. Wani gwaji na biyu da ya yi a kan mutane 48 da ke riga suna kan magani ya nuna HbA1c ya sauka daga 8.1 % zuwa 7.3 % haka kuma HOMA‑IR ya ragu da 44.7 %. Amma waɗannan ƙananan bincike ne a tsakanin masu ciwon suga, kuma kusan kashi ɗaya‑uku na mahalarta sun fuskanci matsalolin hanji. Ga abin da bayanai suke nuna, abin da ba su nuna ba, da abubuwan da ya kamata ku sani kafin ku yanke shawarar amfani da berberine.
Vitamin D3 Ya Dakile Raguwar Telomere da 140 Base Pairs a Gwajin RCT na Shekaru 4
Wani babban gwaji mai kulawa da placebo ya gano cewa shan vitamin D3 tsawon shekaru hudu ya rage raguwar telomere da kusan 140 base pairs. Bayanai sun fito daga binciken VITAL da aka gudanar a kan manyan 'yan Amurka masu shan 2,000 IU a kowace rana. Tasirin ya kasance kanana (p = 0.039), kuma tsawon telomere alama ce kawai, ba hujjar tsawon rai ba. Omega‑3 a wannan gwaji ba ta nuna wani tasiri kan telomere ba. Ga abin da lambobin ke nuna, iyakokinsu, da yadda za a fassara sakamakon.
Gram 2.5 na Peptide Collagen Ya Rage Tabon Idanu da Kashi 20% Cikin Makonni 8
Collagen ɗaya daga manyan abubuwan da ake nema a fannin kwalliya da tsawon rai, amma mafi yawan samfuran suna da takardun placebo ne kawai. A wani gwaji da mata 114 masu shekaru 45‑65 suka halarta, gram 2.5 na takamaiman peptide mai aiki Verisol ya rage ƙyallin tabon idanu da kashi 20 % idan aka kwatanta da placebo bayan makonni 8. Biopsies sun nuna ƙaruwa a procollagen I da kashi 65 % da elastin da kashi 18 %, yayin da ƙaruwa a fibrillin (6 %) ba ta da muhimmanci.
Calcium Alpha‑Ketoglutarate Ya Kara Tsawon Rayuwar Berayen Mata Har Zuwa 16.6% – Menene Ake Nufi Da Abin Da Ba A Nufi Ba?
Binciken da aka wallafa a mujallar *Cell Metabolism* (2020) ya nuna cewa ciyar da berayen da suka kai tsakiyar shekarunsu da abincin da ke ɗauke da 2 % calcium alpha‑ketoglutarate (CaAKG) ya ƙara wa mata tsawon rai har zuwa 16.6 % kuma ya rage kamuwa da rauni. Amma sakamakon ya shafi beraye ne kawai, ba ya nufin zai yi tasiri iri ɗaya a jikin ɗan adam ba.
Spermidine da ƙwaƙwalwa? Binciken watanni 12 a kan manya 100 bai nuna amfanin da placebo
An ƙara spermidine a tallace‑tafi da shi a matsayin kariyar kwakwalwa bisa ga binciken autophagy da gwaje‑gwajen dabbobi. Gwajin SmartAge ya yi wa wannan zato gwaji a kan manya 100 masu raguwar tunani na kai, inda aka ba su kusan mg 0.9 na spermidine a rana tsawon watanni 12. Sakamakon farko ba ya bambanta da placebo (bambanci ‑0.03; P = 0.47), haka kuma sakamakon na biyu ba ya nuna wani tasiri. Alamu na binciken ƙarin suna nuna alaka da ƙurajen jiki da ƙwaƙwalwar magana, amma har yanzu ba a tabbatar da su ba.
1,000 mg Nicotinamide Riboside a Kullum Yana Kara NAD+ a Kwayoyin Jini Da Kusan 60 % a Manyan Mutane, Binciken Randomized Ya Gano
Binciken da aka wallafa a 2018 a *Nature Communications* ya gwada nicotinamide riboside (NR) a 500 mg sau biyu a rana (jimillar 1,000 mg a rana) tsawon makonni shida a manyan da ke da ƙoshin lafiya. An tabbatar da cewa ba a samu illa ba, sannan amfanin NR ya haɓaka matakin NAD+ a cikin ƙwayoyin garkuwar jini da kusan kashi 60 % idan aka kwatanta da placebo. Masu binciken sun kuma lura da alamu na raguwar hauhawar jini da sassauta jijiyoyin jini, amma ba su da hujja da za su tabbatar da fa’ida, don haka an buƙaci ƙarin gwaje‑gwaje.
Nasara Ta Farko Na NMN a Mutane: 250 mg a Kullum Ya Kara Sensitivity Na Insulin a Tsokar Ƙashi Da Kimanin 25 % a Mata Masu Pre‑diabetes
NMN an dade ana ɗaukar shi a matsayin ‘tauraron ƙasa’ wajen tsawaita rai, amma hujjar ɗan adam ta zo ne ne da sakamakon gwajin Washington University na 2021 da aka wallafa a *Science*. A cikin mata masu post‑menopausal da ke da pre‑diabetes, shan 250 mg na NMN a kowace rana tsawon makonni 10 ya inganta insulin‑sensitivity a tsokar ƙashi da kusan kashi 25 %. Sai dai ba a ga wani tasiri kan matakin sukari a jini ko canjin pre‑diabetes ba.
Taurine, Sinadarin Amino Mai Araha da Ya Tsawaita Rayuwar Kunkuru da Kusan 12% Kuma Yana Raguwa da Yawan Taurine a Jinin Mutane
Binciken *Science* na 2023 ya gano cewa matakin taurine a jini – sinadarin amino mai araha da ake samu a ko'ina – yana raguwa da tsufa a cikin kunkuru, birai da mutane. Sa ran taurine ga kunkuru a tsakiyar rayuwa ya ƙara musu tsawon rai da kusan kashi 10‑12% tare da inganta lafiyarsu gaba ɗaya. An ga taurine na rage alamun tsufar ƙwayoyin, lalacewar DNA, matsalolin mitochondria da kumburin da ake kira “inflammaging”. Duk da haka, hujjojin daga mutane na ƙalla‑kalla ne, kuma ƙididdigar da aka samu a kunkuru tana nufin gram‑grama da yawa a kullum. Saboda haka masana sun ƙara jaddada buƙatar ƙarin gwaje‑gwaje kafin a ɗauki taurine a matsayin maganin tsufa.