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Peptides

Epithalon Na Kunnawa Telomerase a Kwayoyin—Ba a Mutane

Helix Ward · · 5 min read

Epithalon Na Kunnawa Telomerase a Kwayoyin—Ba a Mutane

Gajeren bayani: Epithalon peptide ne mai ƙwayoyin amino huɗu da ake cẽwa yana kunna telomerase – wani enzyme da yawancin ƙwayoyin manya ke rasa – sannan ya tsawaita telomeres a ƙwayoyin ɗan adam. Wannan bincike ne ya haifar da sha’awar “tsawon rai” da ake yiwa Epithalon suna. Amma an yi gwajin ne a kan fibroblasts na jariri a cikin tukunya, ba a kan mutane ba; kuma zato game da tsawaita rayuwa ba shi da tushe a wannan takarda. Anan za ku ga abin da nazarin 2003 ya nuna, abin da ba ya nuna, da kuma yadda za ku tantance shi kafin ku yanke shawarar siyan wani abu.

Peptide ɗin da ke ƙunshi amino acid huɗu ne, wato Ala‑Glu‑Asp‑Gly, kuma an ƙirƙira shi a rukunin bincike na Rasha da Vladimir Khavinson ke jagoranta. An fi saninsa da suna Epithalon (ko Epitalon). A mafi yawan wallafa, an danganta sakamakonsa da wannan ƙungiya, don haka yana da muhimmanci mu fahimci iyakokin da ke cikinsa.

Takaitaccen Bayani

A wani takarda da aka buga a 2003 a Bulletin of Experimental Biology and Medicine, Khavinson, Bondarev, da Butyugov sun rubuta cewa ƙara Epithalon zuwa *human fetal fibroblasts (fibroblasts ɗin jariri da ba su da telomerase a yanayi na al'ada) ya haifar da abubuwa guda uku:

  • Bayyanar sashen catalytic na enzyme telomerase (hTERT).
  • Samuwar aikin telomerase da za a iya auna shi.
  • Tsawaitar telomere a waɗannan ƙwayoyin.

Masu rubutun sun yi nuni da cewa wannan yana nuna “yiwuwar” farfarar telomerase a ƙwayoyin somatic, kuma suna ganin hakan na iya nuni da yiwuwar tsawaita rayuwar ƙwayoyin da dukan mutum. Sai dai wannan kuskuren fassara ne kawai; takardar ba ta ƙunshi wani hujja na tsawaita rayuwa ba, kuma ta tsaya a gwajin al'ada ne.

Me Ya Sa Telomerase Ke Jan Hankali?

Telomeres sune ƙusurwar DNA da ke a ƙarshe na kowanne chromosome. A mafi yawan ƙwayoyin somatic, telomeres suna ragowa a kowane rabon kwaya. Idan sun yi gajarta ƙwarai, ƙwayoyin na daina rabuwa ko su shiga yanayin ɗaukar tsufa. Telomerase enzyme ne da ke ƙara sassa na telomere; sashen catalytic ɗinsa, hTERT, yana iyakantacce a ƙwayoyin manya. Saboda haka, wani sinadari da ke kunna hTERT kuma ya tsawaita telomeres a ƙwayoyin da ba su da telomerase a al'ada yana da matuƙar sha’awa.

Amma “kunna telomerase” na da fuskoki biyu: a cikin wani yanayi, hakan na iya haifar da ciwon daji, domin ƙwayoyin da ke da telomerase mai ƙarfi suna iya ci gaba da rabuwa ba tare da iyaka ba. Don haka, muhimmin tambaya ita ce: shin peptide ɗin na iya yin wannan a jikin ɗan adam ba tare da haifar da matsala ba?

Menene Epithalon?

Epithalon peptide ne da aka fi sani da Ala‑Glu‑Asp‑Gly. An ƙirƙire shi a ƙungiyar bincike ta Rasha, inda aka kwatanta shi da epithalamin – wani sinadari da pineal gland ke fitarwa. Duk da cewa mafi yawan binciken da aka wallafa sun fito ne daga wannan ƙungiya, wannan ba yana nufin sakamakon ba su da inganci ba; aƙalla buƙatar gwaje‑gwajen da ba su da alaka da kamfanin talla akwai.

Iyakokin Da Ke Gaskiya

1. Gwaji ne na kwayoyin al'ada

An yi amfani da fibroblasts na jariri, wato ƙwayoyin da suka fi matasa kuma an girka su a cikin yanayin dakin gwaje‑gwaje. Waɗannan ƙwayoyin ba su da tsarin garkuwar jiki, hormones, tsarin ƙashi, metabolism, ko kuma hanyoyin sadarwa na jiki. Saboda haka, sakamakon da aka samu a cikin tukunya ba lallai ne ya wuce zuwa ga jikin mutum ba.

2. Ba a yi gwajin kan mutum ba

Takardar ba ta kunshi wani ɗan adam da aka ba da Epithalon ba, kuma ba ta ba da bayanai kan ƙuduri, amincin, hanyar bayarwa, ko tasirin a kan kwayoyin ɗan adam.

3. Ba ta nuna tsawaitar rayuwa ba

Kalmar “yiwuwar tsawaitar rayuwa” da ke cikin takardar na nufin yiwuwa a matakin ƙwaya ne, ba a ma'anar tsawon lokaci na lafiya ko tsawon rayuwa a mutum ba. Tsufa na da hanyoyi da dama – ciki har da oxidative stress da gajartawar DNA – waɗanda ba su da alaka kai tsaye da telomeres kawai.

4. Takarda ɗaya ce a farkon bincike

Sakamakon yana fitowa ne daga gwaji guda. Don samun sahihiyar hujja, ana buƙatar gwaje‑gwaje da yawa – daga laboratori masu zaman kansu, ƙwayoyi daban‑daban, bayanai kan amsa da ƙuduri, har zuwa gwaje‑gwajen klinik na mutane.

5. Hadarin daji ba a magance ba

Kunna telomerase na iya ƙara haɗarin ciwon daji. Wannan takarda ba ta tabo wannan haɗari ba, kuma ba za a iya ɗaukar ta a matsayin shaida ta amincin lafiyar ɗan adam ba.

Menene Wannan Ke Nufi Ga Masu Son Saya?

Idan ka na tunanin sayen Epithalon, ga wasu abubuwan da ya kamata ka duba kafin ka kashe kuɗi:

Abin da takardar ke tallafawa:

  • Epithalon na iya “kunna” hTERT, samar da aikin telomerase, da tsawaita telomere a fibroblasts na jariri a cikin tukunya.
  • Wannan ya sa peptide ɗin ya zama wani abu mai ban sha’awa a fannin binciken dakin gwaje‑gwaje.

Abin da takardar ba ta tallafawa ba:

  • Cewa Epithalon zai tsawaita telomere a mutane da suka sha shi.
  • Cewa yana rage ko maido da tsufar ɗan adam.
  • Cewa akwai ƙuduri, zagaye, ko hanyar amfani da ke da inganci da aminci a jiki.
  • Cewa kayayyakin da ake sayarwa a layi suna ɗauke da ainihin Epithalon kamar yadda aka rubuta a takardar.

Tambayoyi muhimmai kafin siye:

  1. Shin mai sayarwa yana gabatar da Epithalon a matsayin “kimiyyar bincike” amma yana mai da hankali kan fa’idar ɗan adam? Wannan alamar gargaɗi ce.
  2. Shin an yi gwajin inganci daga ɓangare na uku don tantance tsabta da sahihancin samfur?
  3. Shin Epithalon an amince da shi a matsayin magani a ƙasarka? A yawancin ƙasashe ba a amince da shi ba don amfani a kan ɗan adam.
  4. Ka tattauna da likita, musamman idan kana da tarihin cutar daji ko na iyali.

Kammalawa

Binciken 2003 na da matuƙar ban sha’awa: peptide ƙanƙani da ke nuna alamar farfarar telomerase a fibroblasts na jariri a cikin tukunya. Wannan shi ne matakin farko, ba amsa ba. Yin gagarumin tashi daga “telomere da aka tsawaita a cikin tukunya” zuwa “kayan da zai tsawaita rayuwarka” yana buƙatar shaidar da ta wuce gwaje‑gwajen ɗan adam.

Don haka, a yanzu, Epithalon yana nan a matsayin wani abu mai ban sha’awa a dakin gwaje‑gwaje. Sai dai har sai an samu ƙarin bincike da aka gudanar a kan mutane, ƙara da’awar cewa zai tsawaita rayuwar ɗan adam ba ta da tushe.

Wannan rubutu yana nufin ilimi kawai, ba shawarwarin kiwon lafiya ba.

Original study

Read the original research on pubmed.ncbi.nlm.nih.gov →

This article summarizes published research for general information. It is not medical advice.

HW

Written by

Helix Ward

Helix Ward writes for Biocracked: biohacking science, longevity & human performance.

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