NR + Pterostilbene na ƙara NAD+ kusan 40–90 % a Gwajin Dan Adam
Shin kowane kwayar NR da pterostilbene na iya ɗaga matakin NAD+ a manya? A gwajin farko akan mutane (NRPT – Basis), mutane 120 masu shekaru 60‑80 sun sha shi na tsawon mako takwas. Hakan ya haifar da ƙaruwa kusan 40 % a ƙimar da ake bada shawara, kuma kusan 90 % a ƙimar da ta ninka. Wannan ƙaruwa ta ci gaba da kasancewa duk tsawon gwajin, ba tare da wani haɗari mai tsanani ba. Ga abin da lambobin suka nuna, yadda za a fassara ƙimar, da kuma abubuwan da binciken ba zai iya amsa ba.
Rapamycin Sau Daya a Kowane Mako na Shekara: Lafiya, Amma Shin Kitse na Ciki Ya Sauya?
Kowa na son sanin ko shan rapamycin sau ɗaya a mako zai rage kitse a cikin ciki kuma ya ƙara tsawon lokacin lafiya. Gwajin PEARL ya ba da amsoshi masu ban mamaki: bayan makonni 48 da aka yi wa manya masu lafiya, ba a ga wani canji a adadin kitse na ciki ba, kuma amincin maganin ya yi kama da na placebo. Wasu alamu na biyu – kamar ƙaruwa a ƙwayar ƙiba da rage radadi a mata masu sha 10 mg, da kuma jin daɗi mafi kyau a ƙungiyar 5 mg – suna nuna yiwuwar fa'ida, amma sakamakon na ƙananan rukuni ne kuma ba su tabbatar da tsawaita rayuwa ba. Ga abin da aka samu da abin da ba a samu ba.
Gram 2.5 na Peptide Collagen Ya Rage Tabon Idanu da Kashi 20% Cikin Makonni 8
Collagen ɗaya daga manyan abubuwan da ake nema a fannin kwalliya da tsawon rai, amma mafi yawan samfuran suna da takardun placebo ne kawai. A wani gwaji da mata 114 masu shekaru 45‑65 suka halarta, gram 2.5 na takamaiman peptide mai aiki Verisol ya rage ƙyallin tabon idanu da kashi 20 % idan aka kwatanta da placebo bayan makonni 8. Biopsies sun nuna ƙaruwa a procollagen I da kashi 65 % da elastin da kashi 18 %, yayin da ƙaruwa a fibrillin (6 %) ba ta da muhimmanci.
1,000 mg Nicotinamide Riboside a Kullum Yana Kara NAD+ a Kwayoyin Jini Da Kusan 60 % a Manyan Mutane, Binciken Randomized Ya Gano
Binciken da aka wallafa a 2018 a *Nature Communications* ya gwada nicotinamide riboside (NR) a 500 mg sau biyu a rana (jimillar 1,000 mg a rana) tsawon makonni shida a manyan da ke da ƙoshin lafiya. An tabbatar da cewa ba a samu illa ba, sannan amfanin NR ya haɓaka matakin NAD+ a cikin ƙwayoyin garkuwar jini da kusan kashi 60 % idan aka kwatanta da placebo. Masu binciken sun kuma lura da alamu na raguwar hauhawar jini da sassauta jijiyoyin jini, amma ba su da hujja da za su tabbatar da fa’ida, don haka an buƙaci ƙarin gwaje‑gwaje.
Nasara Ta Farko Na NMN a Mutane: 250 mg a Kullum Ya Kara Sensitivity Na Insulin a Tsokar Ƙashi Da Kimanin 25 % a Mata Masu Pre‑diabetes
NMN an dade ana ɗaukar shi a matsayin ‘tauraron ƙasa’ wajen tsawaita rai, amma hujjar ɗan adam ta zo ne ne da sakamakon gwajin Washington University na 2021 da aka wallafa a *Science*. A cikin mata masu post‑menopausal da ke da pre‑diabetes, shan 250 mg na NMN a kowace rana tsawon makonni 10 ya inganta insulin‑sensitivity a tsokar ƙashi da kusan kashi 25 %. Sai dai ba a ga wani tasiri kan matakin sukari a jini ko canjin pre‑diabetes ba.
Urolithin A, Postbiotik na Rummukan, Yana Kawo Tasirin Mitophagy a Manyan Mutane
Urolithin A, wani sinadari da kwayoyin hanji ke samarwa daga polyphenols da ke cikin ‘ya’yan itatuwa da goro, ya dade yana ƙara ƙarfi ga tsokoki a dabbobin da suka tsufa. Gwajin farko a kan manya ya nuna cewa yana da aminci, yana shigowa jini, kuma yana iya canza alamu na mitochondria a tsakanin 500 – 1,000 mg a kowace rana. Nazarin da kamfanin da ke bayan Mitopure ya tallafa ya bayyana alamar kwayoyin da ke nuna ingantaccen lafiyar mitochondria a tsokar ƙashi. Sai dai gwajin yana da iyaka, ya ɗan takaita lokaci, kuma ya fi mai da hankali kan alamu maimakon ƙarfi ko tsawon rai. Anan ne abin da bayanan suka nuna, wa ya kamata su amfana, da matsayin shaidar a halin yanzu.