Metabolism

3 articles

Approach: Macro science. Palette: B, warm.

Extreme macro photograph of raw berberine: a small heap of vivid yellow-orange crystalline powder with needle-like crystal clusters, shot at a low 30-degree angle with a shallow depth of field. Beside it, a dry sliver of Berberis root bark shows its bright yellow inner wood and fibrous grain. The surface is a smooth dark walnut board. Low golden-hour side light from the left makes the crystals glint like amber glass and throws long warm copper shadows across the wood. One tiny electric green highlight reflects off a glass spatula edge in the soft background blur. The mood is quiet and investigative, with rich saturated honey and burnt-orange tones and no blue cast. Photorealistic, microscopy-like texture, no text or labels.

Berberin vs. metformin: pilotsko ispitivanje – od HbA1c 9,5 % do 7,5 %

BY HELIX WARD · 15. окт 2026.

Mala pilotska studija iz 2008. godine uporedila je berberin i metformin kod novodijagnostikovanih pacijenata sa tip‑2 dijabetesom i pokazala sličan efekat snižavanja glukoze. U grupi koja je uzimala berberin HbA1c je pao sa 9,5 % na 7,5 % za tri meseca. Druga studija na 48 osoba koje su već bile na terapiji zabeležila je pad HbA1c sa 8,1 % na 7,3 % i smanjenje HOMA‑IR‑a za 44,7 %. Međutim, radi se o malim studijama, a oko trećine učesnika je prijavila gastrointestinalne nuspojave. Evo šta podaci zaista pokazuju, šta ne pokazuju i šta treba znati pre nego što pomislite na berberin.

Approach: Macro science. Palette: D, bold color field.

Extreme close-up microscopy-style photograph of a dense cluster of oval, rod-shaped bacterial cells, rendered as slightly wrinkled, matte, pale cream-white forms with visible surface texture. They rest on a smooth, saturated magenta-pink gel surface. Several cells in the foreground are crisp, while the rest fall into soft shallow depth of field. One cell near the center is split open and visibly hollow, to suggest a dead, heat-treated organism. Camera is a low three-quarter angle, as if through a scanning microscope. Lighting is a single hard, warm-white side light that casts short crisp shadows and creates bright rim highlights. A thin electric green (#00e676) line of reflected light traces the edge of one cell. The mood is stark, curious and quietly skeptical. There is no text and no labels.

metabolism

Crevna bakterija koja je bolje radila mrtva: 29 % prednost Akkermansije

BY HELIX WARD · 15. окт 2026.

U prvom ljudskom ispitivanju *Akkermansia muciniphila*, varijanta koja je pasterizovana (umrla), pokazala je bolje rezultate od žive forme. Insulinska osetljivost porasla je za 28,62 %, a nivo cirkulišućeg insulina pao je za 34,08 % u odnosu na placebo kod prekomerno težih, insulinskom rezistentnih odraslih. Gubitak težine i telesne masti, na koje svi nadaju, nisu postigli statističku značajnost, a neki autori drže patente i su‑osnovali firmu koja prodaje ovu bakteriju. Ovde su sažeti nalazi studije, šta oni ne mogu da vam kažu i na šta obratiti pažnju pre nego što kupite suplement.

A softly lit editorial still life on a pale oat-colored linen surface, shot from a slightly elevated three-quarter angle in a wide landscape frame. At center-left, a small matte white ceramic dish holds a modest pile of fine off-white powder, with a tiny brushed-brass measuring spoon resting beside it. Next to the dish stands a minimalist amber glass supplement bottle with a plain cream label and no readable text. A few capsules spill casually across the linen, some translucent and some opaque ivory.

On the right side of the composition, a ripe blood orange cut in half and a handful of raw almonds sit on a light ash-wood board. A sprig of fresh rosemary adds a muted green accent. A sheer glass of water catches the light and throws a soft, rippled caustic pattern across the fabric.

In the background, out of focus, a woman's hand in a soft sage-green knit sleeve rests near a ceramic mug. This suggests a calm morning routine without showing a face. Behind her, a tall window casts diffused, golden-hour light from the upper left, with gentle shadows and a creamy, shallow depth of field.

The palette is warm and restrained: oat, ivory, terracotta, sage, and amber, with a single pop of coral from the blood orange. A thin, abstract line of muted terracotta paint, like a brushed arc, sweeps across the upper right background. It subtly evokes a rising curve without becoming a literal chart.

The mood is calm, trustworthy, and contemporary, like a premium wellness and science journal feature. The image has crisp focus on the powder and bottle, natural film-like grain, soft contrast, and generous negative space in the upper third for headline overlay. It looks like a high-end editorial photograph with no text, logos, or futuristic elements.

metabolism

Prvi ljudski uspeh NMN‑a: 250 mg dnevno podiglo osetljivost mišića na insulin za oko 25 % kod predijabetičnih žena

BY DR. SYNAPSE · 14. окт 2026.

NMN je dugo bio omiljeni dodatak na tržištu dugovečnosti, ali dokazi na ljudima bili su oskudni sve dok 2021. nije objavljena studija Univerziteta Vašington u časopisu *Science*. Kod postmenopauzalnih žena sa predijabetesom i prekomernom težinom, 250 mg NMN dnevno tokom 10 nedelja poboljšalo je insulinsku osetljivost mišića za otprilike 25 %. Signali insulina u mišiću i geni povezani s remodelacijom mišića takođe su se pojačali, dok u placebo grupi nije bilo promena. Međutim, korist je bila uska i studija nije pokazala da NMN snižava nivo glukoze u krvi niti da preokreće predijabetes.

Metabolism

Berberin vs. metformin: pilotsko ispitivanje – od HbA1c 9,5 % do 7,5 %

Crevna bakterija koja je bolje radila mrtva: 29 % prednost Akkermansije

Prvi ljudski uspeh NMN‑a: 250 mg dnevno podiglo osetljivost mišića na insulin za oko 25 % kod predijabetičnih žena

Berberin vs. metformin: pilotsko ispitivanje – od HbA1c 9,5 % do 7,5 %

Crevna bakterija koja je bolje radila mrtva: 29 % prednost Akkermansije

Prvi ljudski uspeh NMN‑a: 250 mg dnevno podiglo osetljivost mišića na insulin za oko 25 % kod predijabetičnih žena