#muscle-aging

1 article

Approach: macro science. Palette: warm (amber and copper).

Extreme close-up of a freshly sliced king oyster mushroom stem and gill edge, shot at a slight 30-degree overhead angle with a macro lens and shallow depth of field. The pale cream flesh shows individual fibrous hyphae and glistening moisture beads. Warm low-angle golden light rakes across from the left, turning the gill ridges into amber and copper lines with deep honey-brown shadows. A single tiny droplet on the cut surface catches a pinpoint of electric green reflection, as if lit from a hidden source. Background melts into out-of-focus burnished orange and chocolate tones. The mood is quiet, intimate and investigative, with real organic texture and no text.

蘑菇“长寿维生素”通过 H₂S 通路提升老龄大鼠的 NAD+

BY HELIX WARD · 2026年10月17日

真菌化合物麦角硫胺（ergothioneine）因其潜在的抗衰老作用被昵称为“长寿维生素”。最新发表在《Cell Metabolism》上的研究表明，给老龄大鼠补充 ET 后，它们的跑步距离更长、肌肉血管化增强、肌肉量有所提升，同时肌肉 NAD+ 水平也上升。研究追溯这一效应至氢硫化物（H₂S）通路，涉及 CSE、硫化修饰以及酶 cGPDH。敲除 CSE 或 cGPDH，所有益处立即消失。需要强调的是，这仅是动物和体外实验，且有效的鼠剂量约相当于人类常规补剂的十倍。