PB125: The Herbal Nrf2 Blend That Kept Arteries Working in Bed Rest
A botanical Nrf2 activator called PB125, made from rosemary, ashwagandha and luteolin, has now been tested in a small, double-blind human trial. In 24 older adults, two weeks at 200 mg/day raised brachial FMD from 2.8% to 3.8% and popliteal FMD from 1.5% to 2.3%. During five days of bed rest, the blend preserved artery function and antioxidant levels compared with placebo. Younger adults saw no baseline FMD gain, though PB125 protected popliteal FMD during limb immobilization. With only 44 participants and surrogate endpoints, it's a promising signal rather than proof of clinical benefit.
This Supermarket Herb Moved Memory, Anxiety and Sleep Scores
A humble supermarket herb just posted some surprisingly broad results in a randomized, double-blind trial. In 68 university students, 1 g/day of rosemary for a month beat placebo on self-reported memory, anxiety, depression and most sleep measures. Only sleep latency and sleep duration failed to budge. But every outcome was a questionnaire, the study ran at a single center, and the abstract gives no effect sizes. Here is what the trial actually found, what it can't tell us, and how to try rosemary sensibly if you're curious.