Mushroom 'Longevity Vitamin' Raised NAD+ in Aged Rats via H2S Switch
Ergothioneine, the mushroom compound nicknamed the 'longevity vitamin,' just got a mechanism to match its buzz. In a Cell Metabolism study, aged rats given ET ran farther, gained vascularization and muscle, and showed higher muscle NAD+. The effect traced back to a hydrogen sulfide pathway: CSE, persulfidation, and the enzyme cGPDH. Knock out CSE or cGPDH and the benefits vanished. But this is animal and lab work, and the effective rat dose scales to roughly 10x what supplements typically provide.
Fisetin Senolytic Extended Mouse Lifespan—Human Proof Still Missing
Fisetin, a plant flavonoid, emerged as the most potent senolytic among ten compounds in a widely cited 2018 EBioMedicine study. In aged mice, treatment late in life reduced senescence markers, eased age-related pathology and extended both median and maximum lifespan. The catch is that this is mouse and lab evidence, not a completed human longevity trial. This article explains what the researchers found, what the dosing context really means, and who should pay attention as human studies develop.
Weekly Rapamycin for a Year: Safe, But Did Visceral Fat Budge?
Everyone wants to know whether weekly rapamycin can shrink visceral fat and boost healthspan, and the PEARL trial has an answer that may surprise you. After 48 weeks in healthy adults, the primary endpoint of visceral fat did not budge, yet safety looked comparable to placebo. Some secondary signals, including lean mass and pain in women on 10 mg and better well-being on 5 mg, hint at benefits. But those are subgroup and self-reported findings, the drug was compounded, and no one has shown that it extends human lifespan. Here is what the data supports and what it does not.
Vitamin D3 Preserved 140 Base Pairs of Telomere in a 4-Year RCT
A large, randomized, placebo-controlled trial found that four years of vitamin D3 slowed telomere shortening by about 140 base pairs. The data come from the VITAL study of older U.S. adults taking 2,000 IU/day. The effect was modest and borderline significant (p=0.039), and telomere length is a surrogate marker, not proof of a longer life. Omega-3s, meanwhile, did nothing for telomeres in this trial. Here is what the numbers show, what the limits are, and how to use the finding sensibly.
Omega-3 Slowed Biological Aging ~3 Months in a 3-Year RCT
A randomized trial in 777 adults aged 70+ found that 1 g/day of omega-3 slowed several epigenetic aging clocks, by roughly 3 months of biological aging over 3 years. Combining omega-3 with vitamin D (2,000 IU/day) and a home strength routine showed additive benefits on the PhenoAge clock. The catch: the effect is small, the analysis was post hoc, and epigenetic clocks are surrogate markers, not proof of a longer life. This breakdown covers the exact numbers, the limitations, and the practical doses used, plus who should check with a doctor first.
Calcium Alpha-Ketoglutarate Extended Female Mouse Lifespan by Up to 16.6%. Here's What That Does (and Doesn't) Mean for Humans
A 2020 Cell Metabolism study found that feeding middle-aged mice a 2% calcium alpha-ketoglutarate diet extended female median lifespan by up to 16.6% and reduced frailty. The effect was smaller in the second cohort (10.5%), and male survival gains were not statistically significant. Researchers link the benefit to lower systemic inflammation and a proposed rise in IL-10. But this was a mouse-only study, and it does not establish that AKG extends human lifespan. Here is what the data show, how they differ from supplement marketing, and why CaAKG belongs on a research watchlist rather than in a proven protocol.
The First Humans to Take Dasatinib + Quercetin: What a 14-Patient IPF Pilot Did (and Didn't) Show
In 2019, researchers reported the first-ever human use of the senolytic combination dasatinib plus quercetin, in 14 patients with idiopathic pulmonary fibrosis. After three weeks of intermittent dosing, participants showed meaningful gains in 6-minute walk distance, gait speed and chair-stand time, even though lung function itself did not change. The pilot also logged one serious adverse event and frequent respiratory, skin and GI complaints. But this was an open-label, uncontrolled study of a cancer drug paired with a pharmacologic-dose flavonoid, not a supplement protocol. Here's what the trial actually tested, what it found, and how to read it critically.
Taurine, the Cheap Amino Acid That Stretched Mouse Lifespans by Up to 12%, Falls With Age in Humans
A 2023 Science study found that circulating taurine, a cheap and widely available amino acid, declines with age in mice, monkeys and humans. Supplementing middle-aged mice extended median lifespan by roughly 10-12% and improved healthspan in both rodents and monkeys. The compound appeared to curb cellular senescence, DNA damage, mitochondrial dysfunction and inflammaging. Human data remain observational, and the mouse doses scale to several grams a day, so the evidence is far from proof. Here is what the study showed, what doses people have discussed, and why researchers say trials are needed before anyone treats taurine as an anti-aging pill.