#caloric-restriction

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$Approach: Macro science. Palette: D, bold color field. Extreme close-up photograph of taurine crystals, long translucent needle-like prisms with sharp faceted edges, bundled and crossing in a loose cluster. They rest on a saturated tomato-red matte acrylic surface. The camera is a low three-quarter angle with a shallow depth of field, so the front crystals are razor sharp and the back ones melt into soft red blur. A hard, warm key light from the upper left makes the facets glint white and throws crisp, thin red-tinted shadows. A single crystal tip in the foreground catches a tiny edge of electric green (#00e676) light refracted through the glass-like prism. The mood is bold, tense and curious, which suits a paradox in the findings. The image has no text, no labels, and no blue cast.$

longevity

牛磺酸随年龄升高，为什么更能保护老年老鼠？

BY NOVA CHEN · 2026年10月25日

牛磺酸——能量饮料罐背面常见的那种氨基酸——在《Cell》最新报道中出现了意外转折：它在人体和小鼠血液中的浓度会随年龄升高。研究者把老年小鼠的血液牛磺酸水平再提升，结果发现健康寿命延长、败血症死亡率下降。作者提出，危险信号会促使巨噬细胞释放牛磺酸，进而激活 NLRP3 炎症小体；而恢复细胞内的牛磺酸则能抑制这一过程。不过，目前的人体证据仅为观察性关联，尚未在临床上测试补充剂剂量。下面为您梳理文章要点、其他临床试验的剂量信息，以及哪些人群需要谨慎使用。