NR da HIIT ana yawan ɗauka a matsayin dabarun da ke riƙe da tsokar cikin yanayi na ƙuruciya. Sabuwar takardar da aka buga a mujallar *Aging Cell* ta nuna cewa wadannan hanyoyi suna sauya agogon epigenetic na tsoka, amma a bangarori daban‑daban. Shan nicotinamide riboside (NR) na tsawon shekaru biyar ya rage hanzarin tsufa a agogunan PCHannum, MEAT, da DunedinPACE, yayin da horon HIIT na makonni 4‑6 ya ƙara hanzarin tsufa a DunedinPACE. Mitochondria na iya zama mahadi tsakanin su, domin canje‑canjen yawan mitochondria a tsoka suna da alaƙa da canje‑canjen MEAT‑derived EAA. A cikin wannan rubutu za mu fayyace abin da binciken ya nuna, abin da ba ya nuna, da yadda za a fassara sakamakon ba tare da yin gaggawa ba.
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