#geroscience

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Approach: macro science. Palette: bold color field (violet).

Extreme close-up of fisetin crystals, a small cluster of pale yellow needle-like flavonoid crystals with translucent, faceted edges, resting on a smooth glossy deep violet surface. The camera sits low at a shallow three-quarter angle with a very shallow depth of field, so the front crystals are razor sharp and the rest dissolves into soft magenta-violet blur. Lighting is a single crisp, slightly warm studio key from upper left that makes the crystal edges glow and throws long soft shadows across the violet. A few tiny electric green (#00e676) specks of reflected light catch on the crystal tips. The mood is precise, curious and quietly promising, like a sample under inspection, with plenty of clear violet space on the right side of the frame.

Fisetin 清除衰老细胞延长小鼠寿命——尚缺乏人类证据

BY HELIX WARD · 2026年10月16日

Fisetin 是一种植物类黄酮，在 2018 年《EBioMedicine》发表的备受关注的研究中被列为十种化合物里最有效的清除衰老细胞剂。对老年小鼠进行晚期治疗可降低衰老标记、减轻与年龄相关的病理，并延长中位寿命和最大寿命。但这些数据仅来源于小鼠及体外实验，尚未有完成的人体长寿随机对照试验。本文将梳理研究者的主要发现、剂量的真实含义，以及在未来的人体研究中哪些人需要关注。