Fisetin, a plant flavonoid, emerged as the most potent senolytic among ten compounds in a widely cited 2018 EBioMedicine study. In aged mice, treatment late in life reduced senescence markers, eased age-related pathology and extended both median and maximum lifespan. The catch is that this is mouse and lab evidence, not a completed human longevity trial. This article explains what the researchers found, what the dosing context really means, and who should pay attention as human studies develop.
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