A two-year randomized trial in 958 older adults found that a daily Centrum Silver multivitamin modestly slowed two epigenetic aging clocks compared with placebo. PCGrimAge advanced 0.113 years per year more slowly and PCPhenoAge 0.214 years more slowly. The benefit was larger in people who were already aging fast, with PCGrimAge slowed by 0.236 years per year. Cocoa extract with 500 mg of flavanols had no effect on any of the five clocks tested. The effects are small and their clinical relevance is unproven, so this is encouraging rather than conclusive.
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