#senolytics

2 articles

Approach: macro science. Palette: bold color field (violet).

Extreme close-up of fisetin crystals, a small cluster of pale yellow needle-like flavonoid crystals with translucent, faceted edges, resting on a smooth glossy deep violet surface. The camera sits low at a shallow three-quarter angle with a very shallow depth of field, so the front crystals are razor sharp and the rest dissolves into soft magenta-violet blur. Lighting is a single crisp, slightly warm studio key from upper left that makes the crystal edges glow and throws long soft shadows across the violet. A few tiny electric green (#00e676) specks of reflected light catch on the crystal tips. The mood is precise, curious and quietly promising, like a sample under inspection, with plenty of clear violet space on the right side of the frame.

Fisetin senolitički produžio životni vek miševa — ljudski dokaz još uvek nedostaje

BY HELIX WARD · 16. окт 2026.

Fisetin, biljni flavonoid, pokazao se kao najefikasniji senolitič među deset ispitivanih jedinjenja u često citiranoj studiji iz 2018. godine u EBioMedicine. Kod starih miševa, tretman koji je započet kasno u životu smanjio je markere senescencije, ublažio patološke promene povezane sa starošću i produžio i srednji i maksimalni vek. Problem je što su to podaci iz miševa i laboratorije, a ne završeni klinički ispit na ljudima. Ovaj članak objašnjava šta su istraživači otkrili, šta zaista znači kontekst doziranja i ko bi trebao da obrati pažnju dok se ljudske studije razvijaju.

A wide, softly lit editorial still life on a pale warm-gray stone surface, shot from a slightly elevated three-quarter angle. On the left, a small cluster of fresh yellow-gold onions with papery skins, one cut in half to show its pale concentric layers, sits beside a few dusty-red capers and a sprig of dill. These are natural quercetin sources and read as quiet botanical details. In the center, a minimalist glass apothecary dish holds a few small, round, off-white tablets. Beside it, a slim amber glass vial lies on its side with a plain unlabeled cap.

On the right, a neatly arranged clinical element: a vintage-style wooden-handled stopwatch and a crisp paper stride-length measuring tape curled in a loose spiral, hinting at the 6-minute walk test and gait speed measures. Behind these, a softly out-of-focus wall of pale sage green with a subtle shadow of a window frame cast diagonally across it. A single translucent anatomical line drawing of lungs, rendered in fine charcoal ink on cream paper, leans against the wall, its delicate branching bronchi echoing the veining of a nearby green leaf.

Lighting is soft morning daylight from the upper left, creating gentle long shadows and a calm, thoughtful mood. The palette is muted and modern: butter yellow, sage, cream, warm gray, with small accents of terracotta and amber. Shallow depth of field keeps the tablets and onion sharp while the background melts into a creamy blur. Generous negative space across the upper right makes room for headline overlay. The composition feels like a contemporary science journal or wellness-research magazine cover: clean, tactile, restrained, with subtle film grain and natural color grading. No text, no logos, no people, no futuristic elements.

longevity

Prvi ljudi koji su uzeli dasatinib i kvercetin: šta je pilot‑studija na 14 pacijenata s IPF pokazala (i nije pokazala)

BY DR. SYNAPSE · 15. окт 2026.

U 2019. godini istraživači su prvi put izveštavali o upotrebi senolitičke kombinacije dasatiniba i kvercetina kod 14 pacijenata sa idiopatskom plućnom fibrozom (IPF). Nakon tri nedelje povremenog doziranja, učesnici su zabeležili značajno veće razdaljine u testu od šest minuta, brže hodanje i brže ustajanje sa stolice, iako se funkcija pluća nije promenila. Pilot‑studija je zabeležila i jedan ozbiljan neželjeni događaj, kao i česte respiratorne, kožne i gastrointestinalne tegobe. Važno je napomenuti da je ovo bila otvorena, nekontrolisana studija lekova za lečenje raka u kombinaciji sa farmakološkim dozama flavonoida, a ne suplementacioni protokol.