#senolytics

2 articles

Approach: macro science. Palette: bold color field (violet).

Extreme close-up of fisetin crystals, a small cluster of pale yellow needle-like flavonoid crystals with translucent, faceted edges, resting on a smooth glossy deep violet surface. The camera sits low at a shallow three-quarter angle with a very shallow depth of field, so the front crystals are razor sharp and the rest dissolves into soft magenta-violet blur. Lighting is a single crisp, slightly warm studio key from upper left that makes the crystal edges glow and throws long soft shadows across the violet. A few tiny electric green (#00e676) specks of reflected light catch on the crystal tips. The mood is precise, curious and quietly promising, like a sample under inspection, with plenty of clear violet space on the right side of the frame.

Fisetin senolitički produžio životni vijek miša – ljudski dokaz još nedostaje

BY HELIX WARD · 16. lis 2026.

Fisetin, biljni flavonoid, istaknuo se kao najsnažniji senolitički među deset spojeva u široko citiranoj studiji iz 2018. godine u časopisu EBioMedicine. Kod starijih miševa liječenje u kasnoj fazi života smanjilo je oznake senescencije, ublažilo patološke promjene povezane s dobi i produljilo i medijan i maksimalni životni vijek. Problem je što su to podaci iz miševa i laboratorija, a ne dovršeno ljudsko kliničko ispitivanje dugovječnosti. Ovaj članak objašnjava što su istraživači otkrili, što doziranje zaista znači i kome bi trebalo obratiti pažnju dok se ljudska istraživanja razvijaju.

A wide, softly lit editorial still life on a pale warm-gray stone surface, shot from a slightly elevated three-quarter angle. On the left, a small cluster of fresh yellow-gold onions with papery skins, one cut in half to show its pale concentric layers, sits beside a few dusty-red capers and a sprig of dill. These are natural quercetin sources and read as quiet botanical details. In the center, a minimalist glass apothecary dish holds a few small, round, off-white tablets. Beside it, a slim amber glass vial lies on its side with a plain unlabeled cap.

On the right, a neatly arranged clinical element: a vintage-style wooden-handled stopwatch and a crisp paper stride-length measuring tape curled in a loose spiral, hinting at the 6-minute walk test and gait speed measures. Behind these, a softly out-of-focus wall of pale sage green with a subtle shadow of a window frame cast diagonally across it. A single translucent anatomical line drawing of lungs, rendered in fine charcoal ink on cream paper, leans against the wall, its delicate branching bronchi echoing the veining of a nearby green leaf.

Lighting is soft morning daylight from the upper left, creating gentle long shadows and a calm, thoughtful mood. The palette is muted and modern: butter yellow, sage, cream, warm gray, with small accents of terracotta and amber. Shallow depth of field keeps the tablets and onion sharp while the background melts into a creamy blur. Generous negative space across the upper right makes room for headline overlay. The composition feels like a contemporary science journal or wellness-research magazine cover: clean, tactile, restrained, with subtle film grain and natural color grading. No text, no logos, no people, no futuristic elements.

longevity

Prvi ljudi koji su uzeli Dasatinib + Kversetin: Što je 14‑osobna pilot‑studija IPF pokazala (i nije pokazala)

BY DR. SYNAPSE · 15. lis 2026.

Godine 2019. istraživači su izvijestili o prvom ikad primijenjenom senolitičkom spoju dasatinib i kversetin kod 14 pacijenata s idiopatskom plućnom fibrozom. Nakon tri tjedna povremenog doziranja, sudionici su zabilježili značajne dobiti u daljini hoda za 6 minuta, brzini hoda i vremenu ustajanja s stolice, iako se funkcija pluća nije promijenila. Pilotu je zabilježen jedan ozbiljan neželjeni događaj te česte respiratorne, kožne i gastrointestinalne pritužbe. Međutim, radi se o otvorenom, nekontroliranom istraživanju lijeka za rak kombiniranog s farmakološkom dozom flavonoida, a ne o protokolu dodatka prehrani. Evo što je studija zapravo testirala, što je otkrila i kako je kritički pročitati.