#frailty

1 article

Approach: the human outcome. Palette: natural.

A tight, low-angle shot of an elderly person's hands gripping a smooth wooden cane at the top of a sunlit garden path. The hands are weathered and slightly tremulous, with visible veins and thin, spotted skin. Behind them, the blurred figure of a seated older man in a cardigan is just recognizable, with his face out of frame. Warm late-morning daylight comes from the side and picks out the grain of the wood and the texture of the skin. The background is soft green foliage and a gravel path in shallow depth of field. The tones are plant greens, honeyed wood and natural skin. A single fresh leaf in vivid electric green sits in the lower foreground. The mood is quiet, honest and reflective, and it suggests fragility without drama.

Oslabljeni stariji imali su niži nivo NAD+ u krvi. Šta to znači za NMN/NR

BY HELIX WARD · 26. окт 2026.

Nova GeroScience studija na 529 starijih japanskih učesnika pokazala je da osobe sa frailitetom imaju nešto niži nivo NAD+ u krvi, uz oko 13 % manju verovatnoću frailnosti po svakom povećanju od 1 µmol/L. Međutim, rad je presek‑studija, obuhvatio je jedino 32 frailna učesnika i razlika u medijanima iznosila je tek 24 vs 25 µmol/L. Veza se još više oslabila kada su kontrolisali hematokrit, što ukazuje da sastav krvnih ćelija može objasniti deo rezultata. Ovaj tekst objašnjava šta rezultati zaista znače, zašto ne dokazuju da NMN ili NR sprečavaju frailitet i šta treba uzeti u obzir ako razmišljate o suplementaciji NAD‑prekurzorima.