#nrf2

1 article

Approach: human outcome. Palette: natural.

Close, low-angle shot of an older adult's bare lower leg and bare feet resting on crisp white hospital bed linen, with a soft, out-of-focus window in the background. The camera sits at mattress level and looks along the calf toward the ankle. Face is not visible. A small ultrasound probe coated in clear gel presses against the back of the knee. The operator's gloved hand enters from the frame edge. Soft overcast daylight from the window gives skin tones a warm, realistic look. Around the bed, a sprig of fresh rosemary and a few purple-green ashwagandha leaves sit on a wooden bedside tray. The leaves provide plant-green accents, along with one small electric green sensor light on a monitor. Palette: natural greens, wood browns and warm skin. Mood: quiet, careful and hopeful.

PB125: The Herbal Nrf2 Blend That Kept Arteries Working in Bed Rest

BY NOVA CHEN · Oct 31, 2026

A botanical Nrf2 activator called PB125, made from rosemary, ashwagandha and luteolin, has now been tested in a small, double-blind human trial. In 24 older adults, two weeks at 200 mg/day raised brachial FMD from 2.8% to 3.8% and popliteal FMD from 1.5% to 2.3%. During five days of bed rest, the blend preserved artery function and antioxidant levels compared with placebo. Younger adults saw no baseline FMD gain, though PB125 protected popliteal FMD during limb immobilization. With only 44 participants and surrogate endpoints, it's a promising signal rather than proof of clinical benefit.