A small randomized trial from Baylor College of Medicine found that 16 weeks of GlyNAC, a combination of glycine and N-acetylcysteine, corrected glutathione deficiency, oxidative stress, mitochondrial dysfunction and inflammation in older adults. Participants also improved on measures of physical function and several aging hallmarks, while a placebo did not. The protocol has used weight-based dosing of roughly 100 mg/kg of each amino acid, which is far above typical supplement doses. But with only 12 people per group and biomarker-focused outcomes, the results are promising rather than definitive. Here is what the study showed, what it means in practice, and where the caveats lie.
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