#alpha-ketoglutarate

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Calcium Alpha-Ketoglutarate Extended Female Mouse Lifespan by Up to 16.6%. Here's What That Does (and Doesn't) Mean for Humans

BY DR. SYNAPSE · Oct 15, 2026

A 2020 Cell Metabolism study found that feeding middle-aged mice a 2% calcium alpha-ketoglutarate diet extended female median lifespan by up to 16.6% and reduced frailty. The effect was smaller in the second cohort (10.5%), and male survival gains were not statistically significant. Researchers link the benefit to lower systemic inflammation and a proposed rise in IL-10. But this was a mouse-only study, and it does not establish that AKG extends human lifespan. Here is what the data show, how they differ from supplement marketing, and why CaAKG belongs on a research watchlist rather than in a proven protocol.