NMN Ya Kara Yawan Gashi da Kashi 57% a Binciken Dan Adam—Amma Tare da Manyan Matsaloli
NMN, sinadarin da ke ƙara matakin NAD+ kuma masu sha'awar tsawon rai ke nema, an gwada shi a kan gashi a mutane a karon farko. A cikin gwaji na makonni 12 da ya ƙunshi mata 15 masu shekaru 40‑50, yawan gashin da ke cikin yanayin haɓaka (anagen) ya tashi daga 55.9 zuwa 87.7 gashi/cm², yayin da kaurin gashi ya ƙaru daga 75.3 µm zuwa 78.8 µm. Masu halarta sun kuma ba da rahoton ƙarin sheki, lankwasa, da girma. Sai dai, gwajin ya kasance ba shi da rukunin placebo, adadin da aka yi amfani da shi ya ƙunshi ƙima fiye da ta kasuwa, kuma marubutan suna da alaƙa da mai samar da NMN. Ga abin da lambobin ke nuna, abin da ba su iya tabbatar ba, da kuma waɗanda ya kamata a jira.
Abin da Binciken Ya Gaskata
Takardar da aka wallafa a Cosmetics a shekarar 2025 (12(5):204) ta fito daga Fukumoto da ƙungiyarsa. Marubutan suna da alaka da Mitsubishi Corporation Life Sciences, wadda ke samar da NMN.
Tsarin Gwajin
- Nau'in Gwaji: Gwaji ɗaya‑ta‑bayan‑gwaji (pre‑post), duk mahalarta sun sami NMN; babu rukunin kwatanta (placebo).
- Masu Halarta: Mata 15 masu lafiya daga Japan, shekaru 40‑50.
- Tsawon Lokaci: Makonni 12.
- Kimanin NMN: 500 mg a rana, an ba da shi a cikin kwayar giɓin Torula.
- Hanyoyin Auna: TrichoScan don ƙididdigar gashi, electron microscopy (SEM) don hoton cuticle, gwajin sinadarai da hormone a gashi, da tambayoyin VAS (Visual Analog Scale) don jin daɗin mahalarta.
Lura: 500 mg ya fito ne daga wata hira da kamfanin ya yi da manema labarai; a kasuwa, kamfanin yana ba da shawarar 250 mg a rana. Don haka adadin da aka yi amfani da shi a gwajin ba shine adadin da ake siyarwa ba.
Lambobin da Suka Ja Hankalin Jama'a
| Ma'auni | Kafin | Bayan | Muhimmanci |
|---|---|---|---|
| Yawan gashi a yanayin anagen (haɓaka) | 55.9 gashi/cm² | 87.7 gashi/cm² | p = 0.03 |
| Kaurin gashi | 75.3 µm | 78.8 µm | p < 0.01 |
Canjin yawan gashi yana da girma sosai a takarda. Canjin kauri kuwa ƙanana ne – kusan 3.5 µm, wato kimanin 5 % – amma ya kasance na ƙarshe a ƙididdiga. Idan an haɗa ƙaruwa a yawan gashi da ƙaruwa a kauri a cikin yanayin haɓaka, za a iya ɗauka alamar tasiri ne, amma dole ne a tantance a gwaje‑gwajen da aka sarrafa.
Masu binciken sun kuma bayyana:
- Cuticle mafi inganci a hoton SEM.
- Sauye‑sauyen metabolomic a cikin amino acid da hanyoyin makamashi a gashi.
- Babu canjin hormone a gashi da aka lura da shi.
- Rahoton mahalarta na ƙarin sheki, lankwasa, da girma, tare da rahoton rage fashewar gashi.
Me Ya Sa NMN, Kuma Me Ya Sa Gashi?
NMN yana daya daga cikin abubuwan da ke ƙara matakin NAD+, kwayar halitta da ke kula da samar da kuzarin ƙwayoyin halitta. Yayin da NAD+ ke raguwa da tsufa, NMN ya zama sanannen kari a tsakanin masu son tsawaita rai. Follicles na gashi suna da aikin metabolism mai nauyi kuma suna fuskantar yanayin haɓaka, raguwar ƙarfi, da hutu. Ra'ayin da ke bayan wannan bincike shi ne, idan an tallafa metabolism na follicle, za a iya ƙarfafa yanayin haɓaka.
Sauye‑sauyen metabolomic da aka gani a cikin amino acid da hanyoyin makamashi suna da alaka da wannan ra'ayi, amma ba su tabbatar da shi ba. Takardar ta ba da hujjoji ne a kan ƙananan rukunin mahalarta, ba a kan tsarin aiki na gaba‑gaba ba. Rashin canjin hormone na nuni da cewa, idan babu tasiri, ba a bi hanyoyin hormone da magungunan rage asarar gashi ke amfani da su ba.
Babban Gargadi: Babu Rukunin Placebo
Wannan shi ne ɓangaren da ya kamata a kula da shi kafin a yanke shawarar siyan samfur:
- Babu rukunin sarrafawa. Idan babu placebo, ba za a iya tantance ko canjin da aka samu na NMN ne ko na wasu dalilai kamar yanayin yanayi, kuskuren auna, ko tasirin zato ba.
- Ƙananan yawan mahalarta. Mutane 15 kacal, gwaji ne na farko, ba shawara ba.
- Alaka da masana'anta. Marubutan suna da alaƙa da mai samar da NMN. Wannan ba ya kawar da bayanai, amma yana nuni da bukatar gwaji mai zaman kansa.
- Ƙungiyar ƙuntata. Mata masu lafiya shekaru 40‑50 kacal. Ba a gwada maza, manya, yara, ko masu fama da asarar gashi ba.
- Babu gwajin kuraje. Ba a tantance kurajen maza ba, kuma babu wata shaida da ke nuna za a iya juyar da su.
- Sakamakon kai. VAS na sheki, girma da jin gajiya su ne ra'ayin kai, wanda ke iya fuskantar tasirin placebo, musamman ma domin mahalarta sun san suna sha kari.
- Tsawon lokaci ƙanƙanta. Makonni 12 ba su ba da cikakken hoto game da ko sakamakon zai ci gaba ko me zai faru bayan daina shan NMN.
Saboda haka, canjin 57 % a gwaji guda ɗaya ya kamata a ɗauke shi a matsayin alama ce da ke buƙatar ƙarin bincike, ba a matsayin shaidar magani mai ƙarfi ba.
Abubuwan Da Za A Iya Amfani Da Su A Aikace‑Aikace
Kima: Gwajin ya yi amfani da 500 mg a rana na NMN da aka samar ta hanyar giɓin Torula. Samfurin kamfanin a kasuwa yana ba da shawarar 250 mg a rana. Babu wani bincike da ya tantance mafi kyawun kima ga gashi, don haka wannan adadi ne kawai da aka gwada.
Lokaci: Gwajin ya gudana tsawon makonni 12, wanda ya dace da tsarin haɓakar gashi mai sannu. Takardar ba ta ba da shawara game da mafi kyawun lokacin shan ba.
Wanene Zai Iya Sha'awa: Mata masu lafiya a shekarun 40‑50 da ke son inganta ingancin gashinsu, kuma wadanda suka riga suka yi amfani da NMN a matsayin kari gaba ɗaya. Karanta shi a matsayin gwaji, ba a matsayin magani da aka tabbatar ba.
Wanene Ya Kamata Ya Guji Ko Ya Nemi Shawara Daga Likita Da Farko:
- Duk wanda ke neman magani da ya tabbatar da tasiri kan kurajen maza ko asarar gashi da aka tantance a likita, domin wannan gwaji ba ya magance waɗannan yanayi.
- Duk wanda asarar gashinsa ke faruwa da sauri ko a wuri‑wuri, wanda ke buƙatar binciken likita (thyroid, ƙarfe, da sauransu).
- Mata masu ciki ko masu shayar da yara, da waɗanda ke shan magunguna ko suka na da cututtuka masu tsanani, su nemi shawara daga likita, domin ba a gwada waɗannan rukunin ba.
- Duk wanda ke tsammanin sakamako mai ban mamaki daga wani gwaji mara sarrafawa.
Takaitaccen Ƙarshe
Gwajin farko na NMN a kan gashi ya samar da lambobi masu kayatarwa: ƙaruwar yawan gashi a yanayin haɓaka, ƙaruwa ƙanana a kaurin gashi, cuticle masu lafiya, da mahalarta masu farin ciki. Amma gwajin ya ƙunshi mutum 15 kacal, daya ne kawai, yana da alaƙa da masana'anta, kuma babu placebo. Ka yi hankali: NMN don gashi yana da ra'ayi mai ban sha'awa, amma har yanzu yana buƙatar gwaje‑gwaje masu ƙarfi, masu sarrafa placebo, manyan rukunoni, da bambance‑bambancen da suka dace kafin a ce yana da tasiri mai ɗorewa.
