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MOTS‑c explicado: el péptido mitocondrial de 16 aminoácidos que activó AMPK y protegió a ratones de la obesidad inducida por dieta

BY DR. SYNAPSE · 15 oct 2026

Un diminuto péptido de 16 aminoácidos codificado en el ADN mitocondrial, no en el núcleo, activó AMPK en músculo y protegió a ratones de la obesidad inducida por la dieta y la resistencia a la insulina, según un estudio de 2015 publicado en *Cell Metabolism*. MOTS‑c se ha convertido en uno de los nombres más comentados en los círculos de péptidos y biohacking. Sin embargo, se trata de un trabajo de descubrimiento en ratón y a nivel molecular sin datos de resultados en humanos, y MOTS‑c no es una terapia aprobada. Este artículo explica qué es MOTS‑c, cómo parece funcionar a través del ciclo del folato y AMPK, qué mostraron los ratones y qué conclusiones sí o no son válidas.