#epigenetic clocks

1 article

Approach: conceptual metaphor. Palette: bold color field.

Subject: two identical brushed-steel analog pressure gauges side by side on a saturated mustard-yellow seamless backdrop, shot straight-on at eye level with a 85mm lens. The left gauge's needle swings down toward the low end, the right gauge's needle swings up into the high end, so they point in opposite directions. The dials are blank, with only unlabeled tick marks. A tiny electric green glass indicator lamp glows on the left gauge's rim. Lighting is a large softbox from the upper left, giving crisp highlights on the chrome bezels and short, clean shadows on the yellow surface. Shallow depth of field softens the background edges. Mood: playful, precise and tense, a visual argument between two opposing results.

NR smanjio epigenetsku starost mišića, HIIT podigao u suprotnom smjeru

BY HELIX WARD · 2. stu 2026.

NR i HIIT se često promoviraju kao načini da mišići ostanu mladi, ali nova studija u časopisu *Aging Cell* otkriva da njihovi učinci na epigenetske satove mogu biti suprotni. Petomjesečna suplementacija nikotinamid ribozidom (NR) povezana je s usporavanjem epigenetskog starenja mišića, osobito prema PCHannum, MEAT i DunedinPACE satovima. S druge strane, HIIT je pomaknuo neke satove prema bržem starenju, najviše primjetno na DunedinPACE. Vezu između njih mogli bi biti mitohondrije, jer su promjene u mišićnom mitohondrijskom sadržaju korelirane s promjenama u MEAT‑baziranom ubrzanju starosti. Evo što studija zaista pokazuje, što ne, i kako to interpretirati bez pretjeranog uzbuđenja.